Dog Inherited Disease Test
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Note: Due to the variety of breeds and diseases the laboratory is able to test for, kindly contact us with details of the breed and type of test you are looking for so we can advise and quote accordingly.
As a dog breeder or lover, your dog’s well-being and health is surely your main priority. You want to make sure that they stay by your side for longer. Our canine inherited disease test can be a step towards ensuring healthier dogs and preventing diseases. Who’zTheDaddy?’s canine disease test screens which diseases your dog is most susceptible to and the probability that your dog might develop one of these diseases at some point in their life.
A healthier dog and a healthier litter
Canine inherited disease testing can better arm you with the tools to provide your dog with a longer life, however if you are a dog breeder the test becomes a necessity, as it is the most meticulous medium available for selective mating. Hereditary illnesses in the gene pool can be cleared with the help of our canine disease test, and offspring will be born disease-free. If following the results of our DNA test, a dog is shown to carry certain hereditary, disease-causing genes, as a dog breeder you can exclude this dog from mating. This tool also provides potential puppy buyers with assurance that their new pet is not genetically predisposed to a particular disease that may be prevalent in a certain breed.
The table below shows the complete list of diseases that we screen in our canine inherited disease test, the dog breeds which are most likely to suffer from the disease, the symptoms which may manifest in your dog and the short or long term prognosis.
|Type of Disease||Dog Breeds in Which We Are Most Likely to See This Disease||Symptoms and Prognosis|
|Uric Acid DNA Test (Hyperuricosuria)||Bull Dogs, Black Russian Terrier, Dalmatians||Characterised by the formation of bladder stones; the stones causes pain and inflammation in the urinary tract. Blood in urine and frequent urination are often also symptoms. Condition can be life threatening.|
|Degenerative Myelopathy (DM) in Canine Breeds. Also known as chronic degenerative radiculomyelopathy||German Shepherds, Pembroke Welsh Corgi and Boxers||The disease results in muscle weakness and lack of coordination. Dogs often begin staggering or wobbling as they walk. Incontinence and paralysis may also result and dog will lose its ability to walk.|
|Centronuclear Myopathy||Labrador Retrievers (disease was previously known as Labrador muscular myopathy)||Muscle weakness, aversion to exercise and activity; difficulty eating, fatigue. The condition is rarely fatal.|
|Cystinuria||Newfoundlands, Dachshunds, Basset Hounds, English Bulldogs, Chihuahuas. Genetic testing only available for Newfoundlands||Urinary tract blockage, frequent urination, blood in urine and several infections.|
|Exercise Induced Collapse (EIC)||Dogs clinically affected by Exercise Induced Collapse (EIC) will often begin to exhibit leg weakness followed by a complete collapse after just 5 to 15 minutes of strenuous activity.|
|Hereditary Nasal Parakeratosis (HNPK)||Labrador Retrievers||HNPK affected dogs will develop dry, rough crusts on the tip of the nose. In extreme cases, the dog’s nose will crack causing severe discomfort.|
|Multidrug Resistance 1 (MDR1)||MDR1 affected dogs are at risk of developing neurologic symptoms from several common drugs.|
|Progressive Retinal Atrophy, Progressive Rod-Cone Degeneration (PRA-prcd)||PRA-prcd is inherited as an autosomal recessive disease. Degeneration of both rod and cone photoreceptor cells of the retina of PRA-prcd affected dogs usually occurs 3 to 5 years of age or later.|
Science behind the test
Our Canine inherited disease test examines your dog’s DNA for SNPs (single nucleotide polymorphisms), which are genetic tellers of possible diseases. SNPs are what influence disease risk. Polymorphisms are variations in the sequence of a particular genetic molecule that might cause diseases. The vast majority of dogs would share the same SNPs or DNA sequences which are distributed over their 46 chromosomes. However, in some dogs, there may be some small changes in a sequence (an SNP). Some of these sequences have no effect or may have no impact or effect but other changing in sequences could mean your dog is at risk of a certain disease. Disease-causing genes are inherited from one or two of the dog’s parents with the risk increasing when both the mother and the father carry the genes. There are no means to identify carrier or affected dogs before the onset of clinical signs, making it difficult to eliminate these diseases from the breed. This is where canine inherited disease testing could be a life saver.
Samples for this DNA test are collected by means of a DNA test kit that we will send out following your order. You will need to collect the samples yourself from the dog/s that required testing by using the oral swabs inside the kit. Sample collection is absolutely painless for the dog and can be safely carried out on puppies too. You may need some assistance in more boisterous or agitated dogs as you will need to rub the swab inside their mouth for ten seconds in order to collect a sample – somebody to hold the dog’s head firmly may help depending on the dog.
What will my results look like?
Your dog may be clear, in which case no copy of the gene that causes the disease is present, and in turn its puppies will also be clear, as long as the dog being bred with is also clear. In the case that one parent carries the gene, offspring have a 50/50 chance of having inherited the disease or being clear.If your dog has inherited one copy of the disease-causing gene, then it is a carrier, meaning that it can pass that disease to its offspring. In the case that your dog is affected, it has two copies of the gene that causes the disease, and will be medically affected by it. The offspring of two affected dogs will all inherit the gene, while offspring of just one affected parent will have a 50% chance of inheriting the gene.
How long do results take to be issued?
Results for our canine inherited disease test will take 10 working days from receipt of samples.
Do you test for diseases in other dogs?
We currently can only offer DNA testing for the breed listed in the table above.